Lynn's comment should be taken seriously: check the weather forecast for your intended route. I was contemplating heading down via Innsbruck, but the forecast for the Brenner pass for Friday is a high of 2C, a low of -4C, and snow. A route down through Switzerland to Lugano may be okay; further west, the route Google prefers goes via Chamonix and past Mont Blanc: a high of 2 and a serious low of -9C on Friday, with rain and snow. I may well decide to be a wimp, blast down the autoroute via Lyon and Chambery and aim to get close to Turin for my evening stop.
Regards,
Martin