No problem on I-75 near Toledo. The potential problem would be construction on I-75 north of the I-475 exit between there and Detroit.
To avoid that, you would simply take the I-90 exit to I-280 to I-75, then to avoid construction on I-75 NORTH of Monroe, and north of the I-475 exit, take I-475 to I-94 East, to I-96 and that will take you straight to the bridge. It's not complicated at all and you will be on a freeway all the way, no war zones.
If you take US-23 to Flint and then I-69 to Port Huron, Google maps tells me that would add 71 miles and 43 minutes. And you would need to get a corner receipt at Flint, BTW. That would add a few more minutes. You could get a receipt at the Speedway ( 24/7 ) station at the Bristol Road exit.
But I recommend crossing back in Detroit on the Ambassador bridge. No good reason not to, but it's your decision, of course.
Good luck, be safe, and watch out for those 18-Wheelers & Cagers.