Good route by Stephen! that avoids a lot of the LA traffic proper; again, truly depends on the day/time that the OP arrives. It's also why I prefaced my prior answer with 'depends on the day'; Sunday morning at daybreak is typically pretty good.
I do recall one trip leaving Camarillo (north-west of the L.A. valley) at about 4:30am on a Sunday and arriving at the eastern end of the Indio metro region (I-10 & CA-86 junction) in 2.5 hours!
My son lives in L.A. these days, so taking the bike truly means navigating traffic as the locals do (as Scott mentioned above...) with proper use of lane-splitting techniques.
At the end of a long motorcycling day, this may or may not be a prudent move.