I've found my Ducati Multistrada V4S to be an outstanding LD bike. It's comfortable, easy to ride, and was easy to add aux fuel thanks to a crossover hose on the main tank. And so far (44k miles) it's been the most reliable and lowest maintenance bike I've ever owned. I honestly didn't expect that when I bought it.
So it works for me. Would I call it a top three LD bike? Nope. The biggest issue is I'm the only person doing this kind of stuff on the Ducati. The aftermarket is small and mostly for the race-pipes-and-carbon-fiber crowd. I have to do a lot of DIY and figure things out on my own. I enjoy that, but the simple fact is your life will be a lot easier with a GS, FJR, or Gold Wing. Those are phenomenal LD bikes with established aftermarkets, and the knowledge base in this community is vast. Need to add lights to a GS? Aux fuel on an FJR? There are folks who can tell you how, and off-the-shelf options available for sale.
We all agree the GS, FJR, and Wing perform well for LD riding. I think the momentum they have in this community is also an important reason why they're great choices.
You can be a weirdo and ride a Ducati or Husqvarna, but you'll be on your own.