Not sure it's possible.
There are long stretches of US50 that are easy to follow and map. But there are chunks, generally in and around cities, that are difficult to deal with using digital navigation.
In my case I carefully followed the route using Google maps prior to the ride. I paid extra attention to confusing spots, made notes, studied, etc. With all that I still ended up backtracking a few times. The hardest part of this ride is making sure you hit all the pieces of US50 correctly. At one point I had to stop on the side of the road and break out my computer to figure out where US50 went. In the end it all worked out.
Also, be prepared to document detours. Have the camera ready and know how to drop pins for documentation...
Good Luck!